A. Cuneyt Tas   Ph.D.         Photo 1    Photo 2    Photo 3

 

66D Old New Brunswick Road

Piscataway, New Jersey 08854

USA                                        E-mail: c_tas@hotmail.com

           

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* Link Accomplishments and citations to published articles        * Google Scholar citations

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* Peer-reviewed Journal Articles                

* Patents                         

* Peer-reviewed Book Chapters         

* International Symposium Talks & Presentations          

* Supervised Graduate Theses

* Work Experience

* Teaching Experience                                         

* Education                    

* Professional Memberships                                  

* Powder X-ray Diffraction Patterns

* Awards & Research Funds                      

* Phase Diagrams           

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* Monodisperse, Amorphous Calcium Phosphate Nanoparticles

* Why (and how) did researchers of the previous century use blood plasma-like synthetic biomineralization solutions, instead of distilled or deionized water, to synthesize biomimetic calcium phosphates?

* Aragonite coating solutions (ACS)

* Manufacture of porous granules from a biocement

* The use of “calcium metal:” How to synthesize calcium phosphates in biomimetic saline solutions, over the pH range of 9 to 12.5, without adding any strong base such as NH4OH, NaOH or KOH?

* Biocompatible calcium phosphates with a BET surface area of 900 m2/g

* Partial Regeneration of Collagen from Water-Soluble Gelatin upon Cooling

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* Recent research accomplishments noted in the March 2014 issue of the Bulletin of The American Ceramic Society

and

in the Fourth Quarter 2014 issue of Biomaterials Forum (of the Society for Biomaterials)

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* Journal and Book Cover Images  (download photos: 1 & 2)

1. February 2005 / Journal of Materials Science: Materials in Medicine

2. December 2004 / Journal of The American Ceramic Society

3. “Dielectric Ceramic Materials,” Ceramic Transactions, Vol. 100, The American Ceramic Society, 1999

* Award Certificates:   links:  1  2  3  @ Clemson University (South Carolina, USA)

* Faculty Awards:   links: 1  2  3  @ METU (Middle East Technical University, Turkey)

* became a university Professor in 2006 (certificate)

* became a university Docent (Associate Professor) in 1997 (certificate)

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Fields of Research

*  Novel aqueous biomineralization media development to synthesize biomimetic biomaterials for bone tissue engineering

*  In vitro - in vivo testing; evaluation of biomaterials according to ISO-10993 standards

*  Bioactive calcium phosphate cement development for skeletal repair, such as the first “monetite (CaHPO4) dental/orthopedic cement” (in 2006) only using Ca(OH)2 powder

*  Biomimetic synthesis of calcium phosphate-based biomaterials for hard tissue regeneration

*  Calcium phosphate-biopolymer (Collagen, Gelatin, Polyvinyl alcohol, Cellulose, etc.) nanocomposites as bone grafts and maxillofacial implants

*  Large surface area inorganic powder and nanorod synthesis

*  Synthesis of macro- and/or micro-porous biomaterials

*  Novel CaCO3 synthesis methods, such as the world’s first (2009) “biconvex micropills” of vaterite; use of CaCO3 in bone graft materials

*  Materials chemistry / Aqueous phase equilibria

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Biomineralization and biomimetic synthesis studies:

+ Developed 8 different biomineralization/calcification media (click the below names of media to reach their peer-reviewed publications):

1.) 27 mM HCO3-Tris-SBF

2.) Lac-SBF

3.) 10xSBF

4.) Brushite-solution

5.) BM-3

6.) BM-7

7.) ACS

8.) SIEM

+ Na-lactate and lactic acid-buffered (i.e., Tris or Hepes-free) “new physiological solution” for in vitro biomineralization experiments or in biomimetic materials synthesis

+ How to prepare and use a Tris-buffered SBF solution (a biomineralization medium) which perfectly mimic the bicarbonate ion concentration (i.e., 27 mM) of human blood plasma?

+ What is biomimetic synthesis? ®High surface area, ionically doped (substituted) Bone-like Calcium Phosphate nano-materials in (Tas-SBF) Synthetic Body Fluids at 36.5°C and pH 7.4

+ Biomimetic synthesis of amorphous calcium phosphate nanoparticles

+ Biomimetic synthesis of poorly crystalline (cryptocrystalline) apatitic calcium phosphate nanoparticles

+ Apatite-like calcium phosphate nanopowders having a BET surface area of 900 m2/g were synthesized at +4°C

+ Simple biomimetic synthesis of monodisperse amorphous calcium phosphate nanospheres (in our BM-7 solution)

+ Enzyme Urease-containing Urea-SBF media for biomaterials synthesis (pH stabilized at 7.4, 36.5°C)

+ A biomimetic procedure for transforming brushite into octacalcium phosphate (OCP, Ca8(HPO4)2(PO4)4×5H2O) in DMEM cell culture solutions at 36.5°C

+ Grade-1, pure titanium immersed in DMEM (Hepes-buffered and phenol red-free) cell culture solution at 36.5°C forms amorphous calcium phosphate (ACP) on its surface

+ Brushite (CaHPO4×2H2O) maturation

+ Comparison of SBF (synthetic body fluid) solutions and bone cell response on coatings obtained from different SBF solutions

+ Na- and K-doped brushite bioceramic and its biomimetic mineralization to nanoapatite

+ 10xSBF solution (another biomineralization medium) for the rapid coating of metals, ceramics or polymers at room temperature

+ DMEM, (Dulbecco’s Modified Eagle Medium; “HEPES-buffered, phenol red-free”) solutions can be used in place of SBF (Synthetic/Simulated Body Fluid) solutions to test the “so-called” in vitro bioactivity of synthetic biomaterials

+ How to use DMEM instead of SBF solutions to test the aqueous calcification potential of synthetic materials (i.e., ceramics, glasses, metals and polymers)?

+ Octacalcium phosphate (OCP, Ca8(HPO4)2(PO4)4×5H2O) bioceramic synthesis in “new biomineralization solutions

+ How to synthesize high thermal stability hydroxyapatite bioceramic powders which will not decompose into b-TCP upon heating above 1400°C?

+ Combustion synthesis: A robust method to incorporate ppm-level biologically relevant ions into synthetic bone graft/bone substitute materials

+ In vitro cell culture studies (see link 1, link 2, link 3, link 4, link 5, link 6, link 7)

+ Developed porous and carbonated calcium phosphate granules; which are already in clinical use

 

Biological cement development for orthopaedic / oral surgery:

+ Self-setting, injectable orthopaedic cement development (see link 1,  link 2,  link 3, link 4, link 5, link 6)

+ the first monetite (Dicalcium phosphate anhydrous = DCPA = CaHPO4) bioceramic cement for orthopedic and dental applications (developed in 2005-2006)

+ Synthesis of tetracalcium phosphate TTCP (Ca4(PO4)2O) bioceramics at 1230°C

+ Synthesis of alpha-tricalcium phosphate (a-Ca3(PO4)2) bioceramics

+ CaHPO4 (monetite)-CaSO4 composite cements for bone tissue engineering

 

Coating of titanium or collagen with biocompatible calcium phosphates:

+ Contact angle measurements and in vitro cell culture on alkali-treated titanium bone implant materials

+ Biomimetic coating of titanium foams for clinical applications and osteoblast proliferation

+ A practical remedy to the problem of “crack formation” in biomimetic coatings (i.e., via synthetic body fluid, SBF) of implants

+ Coating of porous collagen membranes with synthetic bone mineral (i.e., carbonated, Ca-deficient hydroxyapatite)

+ How to coat implant materials with brushite, via aqueous solutions, instead of apatite, at room temperature instead of 37°C?

+ Sol-gel dip coating of Ti-6Al-4V with bioactive apatitic calcium phosphate

 

Novel methods of calcium phosphate biomaterial synthesis:

+ Synthesis of large (6 to 7 microns) particles of carbonated, Na- and Mg-doped apatitic calcium phosphate bioceramic

+ Elemental, metallic calcium (= Ca = calcium metal) (which causes in situ deprotonation in the solutions) used in synthesizing calcium phosphate bioceramics at room temperature

+ Synthesis of macrogranules of brushite (DCPD, CaHPO4×2H2O) and octacalcium phosphate (OCP, Ca8(HPO4)2(PO4)4×5H2O)

+ Produced granules of micro- and macro-porous, carbonated, apatitic calcium phosphate: Calcibon® Granules for hard tissue repair  ® Its Patent &  Its Article

+ Synthesis of microgranules of brushite

+ Completely monodisperse, non-agglomerated and optically transparent single crystals of hydroxyapatite by using the molten salt/flux synthesis (MSS) method

+ Novel technique to synthesize nanowhiskers of apatitic calcium phosphates (Ap-CaP) from CaP powders: “H2O2 solutions at 90°C”

+ How to produce single-phase, well-crystallized b-TCP nanoparticles/nanowhiskers at temperatures less than 250°C by using NaNO3?

+ Porous Bioceramics and Scaffolds

+ Synthesis of struvite (MgNH4PO4×6H2O)

+ The first Rhenanite-apatitic calcium phosphate (NaCaPO4 - Ap-CaP) nano-biphasics

+ Zn-doped apatitic calcium phosphates and Zn-doped TCP for skeletal repair and in vitro cell culture tests

+ Nanowhiskers of non-toxic calcium phosphates by using NaNO3 ® Osteoblast Proliferation

+ Gelatin processing of calcium phosphate bioceramics

 

CaCO3 research:

+ Aragonite coating solutions (=ACS): innovating simple aqueous solutions inspired by the seawater

+ Synthesis of CaCO3 (Vaterite) biconvex micropills or microtablets               Biconvex Micropills of CaCO3 (←missing photo of this link)     CaCO3 micropills   

US Patent 8,470,280 for the first biconvex micropills for any material system known on earth

+ Calcite (CaCO3)-based Macroporous Calcium Phosphate Cements for bone repair

+ Use of Vaterite and Calcite in Forming Calcium Phosphate Cement Scaffolds

+ Vaterite and Aragonite bioceramic synthesis

 

Novel methods of synthesizing electronic and structural ceramics:

+ Mn-doped ZnGa2O4 (zinc gallate) phosphor Nanopowders

+ Synthesis of lanthanum gallate-based solid electrolyte / Solid Oxide Fuel Cell (SOFC) ceramics (see link 1,  link 2, link 3)

+ Use of wet-chemical methods to synthesize nanomaterials: CaZrO3, PbZrO3, LaAlO3, (Y, Ca)(Cr, Co)O3 and Pb(Zr0.52Ti0.48)O3

+ GaO(OH) submicron zeppelins

+ Hydrothermal synthesis of Dysprosium-doped BaTiO3 to circumvent the excessive grain growth phenomena

+ Synthesis of SiO2 spheres, single-phase Enstatite (MgSiO3) and single-phase Cordierite (Mg2Al4Si5O18) using wet chemistry, followed by calcination

+ Developed a low-temperature and upscalable method to synthesize all five calcium aluminate binary compounds of the CaO-Al2O3 system

+ Crystal structure determination by Rietveld Analysis: 1.) Lanthanide pyrosilicates,  2.) Ca-hydroxyapatite,  3.) Ca12Al14O33,  4.) LaAlO3,  5.) Sr- and Zn-doped LaGaO3

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* Older Research Webpages (1993-1998)

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* Sydney Ringer’s historical paper (dated 1882) which led to the development of the “Ringer’s Solution

* Earle’s balanced salt solution (EBSS) paper (dated 1943) and the commercial EBSS recipe containing 27 mM HCO3

* Hanks’ balanced salt solution (HBSS) paper (dated 1949) and the commercial HBSS recipe containing 4.2 mM HCO3

* A milestone paper by E. Hayek and H. Newesely: Synthesis of Hydroxyapatite Powders (1963)

* What is hydroxyapatite? (1968, by E. C. Moreno, T. M. Gregory, and W. E. Brown)

* FTIR and XRD data of NIST-SRM 2910 hydroxyapatite (2004, by M. Markovic, B. O. Fowler, and M. S. Tung)

* Heinrich Vater article on vaterite (1897)

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* How can one evaluate the blood compatibility of synthetic biomaterial surfaces?

* How serious the corrosion of metallic implants could be?

* Could wear particles from metallic implants end up in internal organs?

* Metal particles in liver and spleen from metallic implants

* In vivo degradation of Ti-6Al-4V hip joints with polymer liners

* What should one need to know about silver (Ag) nanoparticles?

* Apollo missions: amino acids found in lunar soil

* Select Biomedical Engineering or Bioengineering Departments in USA