A. Cuneyt Tas Ph.D. Photo
1 Photo
2 Photo 3 Photo 4 Photo 5 Photo 6
Old New Brunswick Road
Piscataway, New Jersey 08854
USA
Contact: https://www.linkedin.com/in/a-cuneyt-tas-ph-d-8a971118/
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* Link →Accomplishments
and citations to published articles * Google
Scholar citations
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* International Symposium Talks &
Presentations
* Patents
* Standard Powder X-ray Diffraction
Patterns
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* Production of micro- and macro-porous materials
* Monodisperse,
Amorphous Calcium Phosphate Nanoparticles
* Why (and how)
did researchers of the previous century use blood
plasma-like synthetic biomineralization solutions, instead of distilled or
deionized water, to synthesize biomimetic calcium phosphates?
* Aragonite
coating solutions (ACS)
* Manufacture
of porous granules
from a biocement
* Monetite (Dicalcium phosphate anhydrous = DCPA =
CaHPO4) bioceramic cement
for orthopedic and dental applications (developed in 2005-2006)
* The use of “calcium
metal:” How
to synthesize calcium phosphates in biomimetic saline solutions, over the pH range of 9 to 12.5, without
adding any strong base such as NH4OH, NaOH or KOH?
* Biocompatible calcium phosphates with a BET surface area
of 900 m2/g
* Partial
Regeneration of Collagen from Water-Soluble Gelatin upon Cooling
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* Recent research accomplishments noted in the March
2014 issue of the Bulletin of The American Ceramic Society
and
in the Fourth
Quarter 2014 issue of Biomaterials Forum (of the Society for Biomaterials)
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* Journal and Book Cover Images (download
photos: 1
& 2)
1. February 2005 /
Journal of Materials Science: Materials in Medicine
2. December 2004 /
Journal of The American Ceramic Society
3. “Dielectric Ceramic
Materials,” Ceramic Transactions, Vol. 100, The American Ceramic Society,
1999
* Award Certificates:
links: 1 2 3 @ Clemson
University (South Carolina, USA)
* Faculty Awards: links: 1 2 3 @ METU
(Middle East Technical University, Turkey)
* became a university Professor in 2006 (certificate)
* became a university Docent (Associate Professor) in 1997 (certificate)
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Fields
of Research
* Novel aqueous biomineralization
media development to synthesize biomimetic biomaterials for bone tissue
engineering
* In vitro - in vivo testing; evaluation of
biomaterials according to ISO-10993 standards
* Bioactive calcium
phosphate cement development for skeletal repair, such as the first “monetite
(CaHPO4) dental/orthopedic cement” (in 2006) only using Ca(OH)2
powder
* Biomimetic
synthesis of calcium phosphate-based biomaterials for hard tissue regeneration
* Calcium
phosphate-biopolymer (Collagen, Gelatin,
Polyvinyl alcohol, Cellulose, etc.) nanocomposites as bone grafts and
maxillofacial implants
* Large surface
area inorganic powder and nanorod synthesis
* Synthesis of
macro- and/or micro-porous biomaterials
* Novel CaCO3 synthesis methods, such
as the world’s first (2009) “biconvex micropills” of vaterite; use of CaCO3
in bone graft materials
* Materials
chemistry / Aqueous phase equilibria
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Biomineralization and biomimetic synthesis
studies:
+ Developed 8
different biomineralization/calcification media (click the below names of media
to reach their peer-reviewed publications):
2.) Lac-SBF
3.) 10xSBF
5.) BM-3
6.) BM-7
7.) ACS
8.) SIEM
+ Na-lactate and
lactic acid-buffered (i.e., Tris or Hepes-free) “new
physiological solution” for in vitro
biomineralization experiments or in biomimetic materials synthesis
+ How to prepare
and use a Tris-buffered SBF solution (a biomineralization medium) which
perfectly mimic the bicarbonate ion concentration (i.e., 27 mM) of human blood
plasma?
+ What is biomimetic synthesis? ®High
surface area, ionically doped (substituted) Bone-like Calcium Phosphate
nano-materials in (Tas-SBF) Synthetic Body Fluids at 36.5°C and pH 7.4
+ Biomimetic synthesis of amorphous calcium phosphate
nanoparticles
+ Apatite-like calcium phosphate nanopowders having a BET
surface area of 900 m2/g were
synthesized at +4°C
+ Simple biomimetic
synthesis of monodisperse amorphous calcium
phosphate nanospheres (in our BM-7
solution)
+ Enzyme
Urease-containing Urea-SBF media for biomaterials synthesis (pH stabilized
at 7.4, 36.5°C)
+ A biomimetic procedure for transforming brushite into octacalcium phosphate
(OCP, Ca8(HPO4)2(PO4)4×5H2O)
in DMEM cell culture solutions at 36.5°C
+ Grade-1, pure titanium immersed in DMEM
(Hepes-buffered and phenol red-free) cell culture solution at 36.5°C forms
amorphous calcium phosphate (ACP) on its surface
+ Brushite (CaHPO4×2H2O)
maturation
+ Comparison of SBF (synthetic body
fluid) solutions and bone cell response on coatings obtained from different
SBF solutions
+ Na-
and K-doped brushite bioceramic and its biomimetic mineralization to
nanoapatite
+ 10xSBF
solution (another biomineralization medium) for the rapid coating of metals,
ceramics or polymers at room temperature
+ DMEM, (Dulbecco’s Modified Eagle Medium;
“HEPES-buffered, phenol red-free”) solutions can be used in place of SBF (Synthetic/Simulated Body Fluid)
solutions to test the “so-called” in
vitro bioactivity of synthetic
biomaterials
+ How to use DMEM instead
of SBF solutions to test the aqueous calcification potential of synthetic
materials (i.e., ceramics, glasses, metals and polymers)?
+ How to
synthesize high thermal stability hydroxyapatite bioceramic powders which
will not decompose into b-TCP
upon heating above 1400°C?
+ Combustion synthesis: A robust method to incorporate
ppm-level biologically relevant ions into synthetic bone graft/bone
substitute materials
+ In
vitro cell culture studies (see link 1, link 2, link 3, link 4, link 5, link 6,
link 7)
+ Developed porous and carbonated calcium phosphate
granules; which are already in clinical
use
Biological cement development for orthopaedic /
oral surgery:
+ Self-setting, injectable orthopaedic cement development
(see link 1, link 2, link 3, link 4, link 5, link 6)
+ the first monetite (Dicalcium phosphate anhydrous = DCPA = CaHPO4)
bioceramic cement for orthopedic
and dental applications (developed in 2005-2006)
+ Synthesis of tetracalcium phosphate TTCP (Ca4(PO4)2O)
bioceramics at 1230°C
+ Synthesis of alpha-tricalcium
phosphate (a-Ca3(PO4)2)
bioceramics
+ CaHPO4
(monetite)-CaSO4 composite cements for bone tissue engineering
Coating of titanium or collagen with
biocompatible calcium phosphates:
+ Contact angle
measurements and in vitro cell
culture on alkali-treated titanium bone implant materials
+ Biomimetic coating
of titanium foams for clinical applications and osteoblast proliferation
+ A practical remedy
to the problem of “crack formation” in biomimetic coatings (i.e., via synthetic
body fluid, SBF) of implants
+ Coating of porous collagen membranes
with synthetic bone mineral (i.e., carbonated, Ca-deficient hydroxyapatite)
+ How to coat implant materials with brushite, via aqueous solutions, instead of
apatite, at room temperature instead of 37°C?
+ Sol-gel dip
coating of Ti-6Al-4V with bioactive apatitic calcium phosphate
Novel methods of calcium phosphate biomaterial
synthesis:
+ Synthesis of large
(6 to 7 microns) particles of carbonated, Na- and Mg-doped apatitic calcium
phosphate bioceramic
+ Elemental,
metallic calcium (= Ca = calcium metal) (which causes in situ
deprotonation in the solutions) used in synthesizing calcium
phosphate bioceramics at room temperature
+ Produced granules of micro- and macro-porous,
carbonated, apatitic calcium phosphate: Calcibon®
Granules for hard tissue repair ® Its Patent
&
Its Article
+ Synthesis of
microgranules of brushite
+ Completely monodisperse, non-agglomerated and optically
transparent single crystals of
hydroxyapatite by using the molten salt/flux synthesis (MSS) method
+ Novel technique to
synthesize nanowhiskers of apatitic calcium phosphates (Ap-CaP) from CaP powders:
“H2O2 solutions at 90°C”
+ How to produce single-phase, well-crystallized b-TCP
nanoparticles/nanowhiskers at temperatures less than
250°C
by using NaNO3?
+ Porous
Bioceramics and Scaffolds
+ Synthesis
of struvite (MgNH4PO4×6H2O)
+ The first Rhenanite-apatitic calcium
phosphate (NaCaPO4 -
Ap-CaP) nano-biphasics
+ Zn-doped apatitic
calcium phosphates and Zn-doped TCP for skeletal repair and in vitro cell culture tests
+ Nanowhiskers
of non-toxic calcium phosphates by using NaNO3 ® Osteoblast
Proliferation
+ Gelatin
processing of calcium phosphate bioceramics
CaCO3 research:
+ Aragonite
coating solutions (=ACS): innovating simple aqueous solutions inspired by
the seawater
+ Synthesis
of CaCO3 (Vaterite) biconvex micropills or microtablets Biconvex
Micropills of CaCO3 (←missing
photo of this link) CaCO3
micropills
US
Patent 8,470,280 for the first biconvex micropills for any material system
known on earth
+ Calcite (CaCO3)-based
Macroporous Calcium Phosphate Cements for bone repair
+ Use of
Vaterite and Calcite in Forming Calcium Phosphate Cement Scaffolds
+ Vaterite and
Aragonite bioceramic synthesis
Novel methods of synthesizing electronic and
structural ceramics:
+ Mn-doped
ZnGa2O4 (zinc gallate) phosphor Nanopowders
+ Synthesis of lanthanum gallate-based solid electrolyte /
Solid Oxide Fuel Cell (SOFC) ceramics
(see link 1, link 2, link 3)
+ Use of wet-chemical methods to synthesize nanomaterials:
CaZrO3, PbZrO3, LaAlO3, (Y, Ca)(Cr, Co)O3
and Pb(Zr0.52Ti0.48)O3
+ GaO(OH)
submicron zeppelins
+ Hydrothermal synthesis of Dysprosium-doped BaTiO3
to circumvent the excessive grain growth phenomena
+ Synthesis of SiO2
spheres, single-phase Enstatite (MgSiO3)
and single-phase Cordierite (Mg2Al4Si5O18)
using wet chemistry, followed by calcination
+ Developed a low-temperature and upscalable method to
synthesize all five calcium aluminate binary compounds of the CaO-Al2O3
system
+ Crystal structure determination by Rietveld Analysis: 1.)
Lanthanide
pyrosilicates, 2.) Ca-hydroxyapatite, 3.) Ca12Al14O33, 4.) LaAlO3, 5.) Sr- and Zn-doped LaGaO3
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* Older Research Webpages (1993-1998)
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*
Sydney Ringer’s historical
paper (dated 1882) which led to the development of the “Ringer’s
Solution”
*
Earle’s balanced salt solution (EBSS) paper
(dated 1943) and the commercial EBSS recipe
containing 27 mM HCO3
*
Hanks’ balanced salt solution (HBSS) paper (dated 1949) and
the commercial HBSS recipe
containing 4.2 mM HCO3
* A milestone paper by E. Hayek and H.
Newesely: Synthesis
of Hydroxyapatite Powders (1963)
*
What is hydroxyapatite?
(1968, by E. C. Moreno, T. M. Gregory,
and W. E. Brown)
*
FTIR and XRD data of NIST-SRM
2910 hydroxyapatite (2004, by M.
Markovic, B. O. Fowler, and M. S. Tung)
*
Heinrich Vater article
on vaterite (1897)
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* How can one evaluate the blood compatibility of
synthetic biomaterial surfaces?
* How serious the corrosion
of metallic implants could be?
* Could wear particles
from metallic implants end up in internal organs?
* Metal particles in
liver and spleen from metallic implants
* In
vivo degradation of Ti-6Al-4V hip
joints with polymer liners
* What should one need to know about silver
(Ag) nanoparticles?
* Apollo missions: amino
acids found in lunar soil
* Amino
acid (glycine) detected in the returned Stardust capsule
* In
vitro production of amino acids – Stanley Miller experiment
of 1952-1953
* Select Biomedical
Engineering or Bioengineering Departments in USA
“Passion is the difference between having a job and having
a career.”
